Organoids — Preclinical Models of Human Disease

by Mo Li, Juan C. Izpisua Belmonte
Year: 2019


Mo Li and Juan C. Izpisua Belmonte.​ "Organoids — Preclinical Models of Human Disease"​ N Engl J Med 2019; 380:569-579


​An organoid is a three-dimensional construct composed of multiple cell types that originates from stem cells by means of self-organization and is capable of simulating the architecture and functionality of native organs. Organoids permit in vivo and in vitro investigation and represent one of the latest innovations in the quest for a model to recapitulate the physiologic processes of whole organisms. ​


Organoid Stem cells