Ground rules of the pluripotency gene regulatory network

by Mo Li, Juan Carlos Izpisua Belmonte
Year: 2017


Mo Li and​ Juan Carlos Izpisua Belmonte. "Ground rules of the pluripotency gene regulatory network"  Nature Reviews Genetics volume 18, (2017): 180–191


​Pluripotency is a state that exists transiently in the early embryo and, remarkably, can be recapitulated in vitro by deriving embryonic stem cells or by reprogramming somatic cells to become induced pluripotent stem cells. The state of pluripotency, which is stabilized by an interconnected network of pluripotency-associated genes, integrates external signals and exerts control over the decision between self-renewal and differentiation at the transcriptional, post-transcriptional and epigenetic levels. Recent evidence of alternative pluripotency states indicates the regulatory flexibility of this network. Insights into the underlying principles of the pluripotency network may provide unprecedented opportunities for studying development and for regenerative medicine. ​


Pluripotency Reprogramming Gene