Deconstruct pluripotency gene regulatory network

by Mo Li, Juan Carlos Izpisua Belmonte
Year: 2018


Li, Mo, and Juan Carlos Izpisua Belmonte. "Deconstructing the pluripotency gene regulatory network." Nature cell biology20, no. 4 (2018): 382.​


Pluripotent stem cells can be isolated from embryos or derived by reprogramming. Pluripotency is stabilized by an intercon-nected network of pluripotency genes that cooperatively regulate gene expression. Here we describe the molecular principles of pluripotency gene function and highlight post-transcriptional controls, particularly those induced by RNA-binding proteins and alternative splicing, as an important regulatory layer of pluripotency. We also discuss heterogeneity in pluripotency regula-tion, alternative pluripotency states and future directions of pluripotent stem cell research.​


Pluripotency Gene regulatory network